A Study on Binding Modes of Nonsteroidal Anti-inflammatory Drugs to COX1 and COX2 as Obtained by Dock4.0

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A Study on Binding Modes of Nonsteroidal Anti-inflammatory Drugs to COX1 and COX2 as Obtained by Dock4.0

Call No. (NDL)
Z17-1611
Bibliographic ID of National Diet Library
4976150
Material type
記事
Author
赤穂 栄一ほか
Publisher
鯖江 : 化学ソフトウェア学会
Publication date
1999-12
Material Format
Digital
Journal name
The Journal of chemical software 5(4) 1999.12
Publication Page
p.147~162
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Detailed bibliographic record

Summary, etc.:

COX1の酵素活性に影響を与えることなくCOX2 を選択的に阻害する薬物が理想的な非ステロイド性抗炎症剤(NSAID)であるといわれている。そこで、Dock4.0を用いて、NSAIDのCOX1とCOX2に対する阻害モードの研究を水素結合と結合エネルギーの点から試みた。COX2に選択性の有るNSAID...

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Digital

Material Type
記事
Author/Editor
赤穂 栄一
藤川 智香子
Howell I. Runion 他
Alternative Title
Dock4.0を用いた非ステロイド性抗炎症剤のCOX1およびCOX2に対する結合モードに関する研究
Periodical title
The Journal of chemical software
No. or year of volume/issue
5(4) 1999.12
Volume
5
Issue
4
Pages
147~162